From St. Louis, take I-55 south to Highway 67 South. Take Hwy 67 South to Farmington for approximately 38 miles and exit to Highway 221 and take a RIGHT. Go through Doe Run, MO and continue about 9 miles. Watch carefully as Hwy 221 makes a left turn — take that left to stay on 221 towards Pilot Knob. At Pilot Knob take Highway 21 South (LEFT) to Lesterville, about 25miles. Again, watch carefully as you need to take a RIGHT to stay on 21 South (just before the two giant smokestacks). Turn LEFT at Lenny’s convenience store onto Peola Road (if you go into downtown Lesterville on 21 South you have gone too far). At the stop sign take RIGHT and go over the Black River bridge. Continue about 1 mile until you come to the Wilderness Lodge entrance.